Prague, Czech Republic, October 4-7, 2017
Scientific Program
Carolinum auditorium of Charles University, Prague, the oldest university on the European continent. Charles University was founded April 7, 1348 by Charles IV, King of Bohemia and Holy Roman Emporer, making it one of the oldest universities of the world. The ET-15 Welcome Reception will be held at the Carolinum.
Wednesday, October 4, 2017
15.00-17.00 Registration
18.00-20.00 Welcome Reception
Venue: Carolinum Hall, Charles University
Thursday, October 5, 2017
Venue: Hotel Duo, Prague
Morning Session
8.00-10.00 Symposium I
Endothelin signaling and mechanisms of endothelin action
Chairs: Pedro d´Orleans-Juste, Augusto C. Montezano
8.00-8.30 Key Note Lecture
Pharmacology of Endothelin Receptors: Prospects for the Next Decade
Anthony P. Davenport, University of Cambridge, UK
10.00-10.30 Coffee Break
10.30-12.00 Symposium II
Pharmacology, new drugs and drug interactions
Chairs: Janet Maguire, Anil Gulati
10.30-11.00 Key Note Lecture
Pharmacological Interventions Targeting the Endothelin Pathway: the Status Quo and Future Perspectives
Noriaki Emoto, Kobe Pharmaceutical University, Japan
12.00-12.15 ET-15 Conference Group Photograph
12.15-14.00 Lunch and Poster Session
Afternoon Session
14.00-15.30 Symposium III
Physiology and pathophysiology of cardiovascular function
Chairs: Noriaki Emoto, Pavel Jansa
14.00-14.30 Key Note Lecture
Endothelin in Resistance Artery Responses of Patients With Cardiovascular Disease
Jo De Mey, University of Odense, Denmark
15.30-16.00 Coffee Break
16.00-17.30 Symposium IV
Pulmonary function and pulmonary hypertension
Chairs: Martine Clozel, Vladimir Tesař
16.00-16.30 Key Note Lecture
Advances in Pathophysiology and Treatment of Chronic Pulmonary Hypertension
Pavel Jansa, Charles University, Czech Republic
18.00-21.00 Young Investigator Event
Friday, October 6, 2017
Morning Session
8.00-10.00 Symposium V
Metabolism, diabetes, metabolic syndrome, and obesity
Chairs: John Pernow, Carmine Cardillo
8.00-8.20 Invited Lecture
Bitter Taste of Diabetic Complications: Endothelin
Adviye Ergul, Augusta University, U.S.A.
8.20-8.40 Invited Lecture
Novel Aspects on Metabolism and Hypertension – The Nitrate-Nitrite-NO Pathway
Eddie Weitzberg, Karolinska Institutet, Sweden
10.00-10.30 Coffee Break
10.30-12.00 Symposium VI
Physiology and pathophysiology of renal function
Chairs: Neeraj Dhaun, Ivana Vaněčková
10.30-10.50 Invited Lecture
Endothelin Receptor Antagonism and Kidney Disease
Donald E. Kohan, University of Utah, U.S.A.
10.50-11.20 Invited Lecture
Endothelin and the Kidney Clock
David M. Pollock, University of Alabama, U.S.A.
12.00-14.00 Lunch and Poster Session
Afternoon Session
14.00-15.30 Symposium VII
Sex differences in physiology and disease
Chairs: Jennifer S. Pollock, Hiromi Yanagisawa
14.00-14.30 Key Note Lecture
The Interplay Between Endothelin-1 and Testosterone in the Activation of the Immune System
Rita C. Tostes, University of Sao Paulo, Brazil
15.30-16.00 Coffee Break
16.00-17.30 Symposium VIII
Neurophysiology, neurobiology, dementia and pain
Chairs: Adviye Ergul, Jo De Mey
16.00-16.30 Key Note Lecture
ETB Receptors Agonist, IRL-1620, for the Treatment of CNS Disorders
Anil Gulati, Midwestern University, U.S.A.
16.30-17.00 Key Note Lecture
A Genetic Variant Associated with Five Vascular Diseases is a Distal Regulator of Endothelin-1 Expression
Rajat M. Gupta, Harvard Medical School, Boston, USA
19.30 Pre-Banquet Reception
20.00 Concert and Conference Banquet
Saturday, October 7, 2017
Morning Session
8.00-10.00 Symposium IX
Immune system and inflammation
Chairs: Ariela Benigni, Josef Zicha
8.30-8.30 Key Note Lecture
Immune Mechanisms in Hypertension
Ernesto L. Schiffrin, McGill University, Montréal, Canada
10.00-10.30 Coffee Break
10.30-12.00 Symposium X
Cancer and metastasis
Chairs: Laura Rosano, Marilena Loizidou
10.30-11.00 Key Note Lecture
Targeting ET-1 Receptor/-Arrestin1 Signaling Circuit in Ovarian Cancer Treatment
Anna Bagnato, Regina Elena National Cancer Institute, Italy
11.30 - 12.30 Lunch
Afternoon Session
12.30-14.00 Symposium XI:
Role of endothelin in selected diseases
Chairs: David M. Pollock, Pierre-Louis Tharaux
12.30-13.30 Key Note Lecture
Balloon Angioplasty and Endothelin
Matthias Barton, University of Zurich, Switzerland
14.00-14.30 Coffee Break
14.30-16.00 Symposium XII:
Endothelin receptor antagonists in clinical trials
Chairs: David J. Webb, Věra Čertíková Chábová
14.30-14.55 Invited Lecture
From Endothelin Research to Drugs
Martine Clozel, Actelion, Switzerland
14.55-15.20 Invited Lecture
Dual Angiotensin II (Ang II) AT1 and Endothelin (ET) Type A Receptor Inhibition With Sparsentan in Primary Focal Segmental Glomerulosclerosis (FSGS): DUET Trial
Radko Komers, Retrophin, U.S.A.
15.20-15.45 Invited Lecture
Endothelin Antagonists in the Treatment of Diabetic Nephropathy – An Update
Vladimir Tesař, Charles University, Czech Republic
15.45-16.00 Award Ceremony
The Fourth Tomoh Masaki Award (2017)
Awards for best oral and best poster presentations
16.00-16.30 Highlights of ET-15
Special Lecture: Masashi Yanagisawa, University of Tsukuba, Japan
16.30-16.40 Closing remarks by the Conference Chairs
Ivana Vaněčková, Czech Academy of Sciences, Czech Republic
John Pernow, Karolinska Institutet, Sweden